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Updated: Aug 24, 2026

Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
Published on: May 22, 2018
Parasympathetic cardiac nerve stimulation with implanted coronary sinus lead
Hajnalka Vágó1, Attila Róka, György Acsády
1Cardiovascular Centre, Department of Cardiovascular Surgery, Semmelweis University, Budapest, Hungary.
Abstract:
A patient with drug-refractory paroxysmal atrial fibrillation associated with rapid ventricular rate underwent biatrial pacemaker implantation. During elective replacement of the pacemaker, a significant voltage- and frequency-dependent decrease in ventricular rate was achieved by high-frequency electrical stimulation (17 Hz) of parasympathetic cardiac nerves innervating the AV node with the implanted bipolar coronary sinus electrode. The negative dromotropic effect of parasympathetic stimulation was eliminated by intravenous administration of 1-mg atropine.
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