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[Embryonic mechanisms in development of spina bifida in humans]

O V Vostrikov1, V A Zotov, E V Nikitenko

  • 1Research Institute of Human Morphology, 117418, Moscow.

Arkhiv Patologii
|May 25, 2004
PubMed

Insights

Spina bifida (SB) arises from disruptions in spinal cord development during early embryogenesis. The timing and duration of these developmental delays determine the type and severity of SB, impacting potential surgical outcomes.

Area of Science:

  • Developmental biology
  • Embryology
  • Neuroscience

Context:

  • Spina bifida (SB) is a complex neural tube defect.
  • Understanding the precise timing of developmental events is crucial for identifying causes of congenital anomalies.
  • Human embryonic and fetal development involves intricate cellular movements and signaling pathways.

Purpose:

  • To investigate the embryonic origins of spina bifida (SB).
  • To correlate specific developmental delays in neurulation with different types of SB.
  • To elucidate the etiological factors underlying SB pathogenesis.

Summary:

  • A study of 86 human embryos and fetuses identified 23 cases of spina bifida (SB).
  • SB is caused by disturbances or delays in the caudal neurulation wave, which forms the spinal cord.
  • The type and severity of SB depend on the timing (22-28 days) and duration (4-20+ hours) of neurulation delays, influencing embryonic survival and potential for surgical intervention.

Impact:

  • Provides a detailed timeline of SB development during embryogenesis.
  • Differentiates SB types based on specific neurulation timing, aiding in prognosis.
  • Offers insights into the mechanisms of congenital spinal cord malformations and potential therapeutic targets.

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