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ELVIRA HSV, a yield reduction assay for rapid herpes simplex virus susceptibility testing
Ruzena Stránská1, Rob Schuurman, David R Scholl
1Department of Virology, Eijkman-Winkler Center, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. r.stranska@azu.nl
Antimicrobial Agents and Chemotherapy
|May 25, 2004
Abstract:
A colorimetric yield reduction assay, ELVIRA (enzyme-linked virus inhibitor reporter assay) HSV, was developed to determine the antiviral drug susceptibilities of herpes simplex virus (HSV). It uses an HSV-inducible reporter cell line. This simple and rapid assay has an objective readout, low inoculum size, and good reproducibility. The results correlate well with those of the plaque reduction assay.