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Polymer-coated liposomes resistant to enzymatic hydrolysis
Takeshi Gotoh1, Mitsunori Hozawa
1Department of Materials-Process Engineering & Applied Chemistry for Environments, Akita University, 1-1 Tagata Gakuen-cho, Akita 010-8502, Japan. tgotoh@ac5.as.akita-u.ac.jp
Biotechnology Letters
|June 1, 2004
Abstract:
A polymerizable electrolyte, 2-aminoethyl 1,6-heptadien-4-yl phosphate (AEHDP), which has the same hydrophilic head group as naturally occurring phospholipids, was prepared. Five equivalents of AEHDP were added to a suspension of liposomes (closed bilayer vesicles made of phospholipids) and layered on the liposomes. After polymerization by UV irradiation, the resulting polymer-coated liposomes were resistant to hydrolysis of their constituent phospholipids by phospholipase A2.