[What vaccination has brought]

The vaccines have improved obviously and constantly the struggle against infectious diseases. When the immunisations have been well applied some diseases fell down dramatically: i.e. diphtheria, poliomyelitis and smallpox which was eradicated. Actually some efficacious vaccines as measles or rubella vaccines could eliminate the diseases. Nevertheless in many developed countries the immunisation coverage is not properly reached and the diseases are always circulating, with a shift of age towards adults, with more severe diseases or new epidemiology (i.e. pertussis). However measles have been eliminated from some countries as Finland, Sweden, United States. The adverse events of vaccines are nowadays enhanced and discourage immunisation among some doctors or patients. The benefit-risk ratio has to be made very clear to avoid a lack or a denial of immunisation after false fears about risk of some vaccines. An improvement of surveillance and of correct information is highly required.