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Updated: Jan 19, 2026
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
Detection of choroidal neovascularization by subtraction indocyanine green angiography
Muneaki Matsumoto1, Kunihiko Shiraki, Akira Obana
1Department of Ophthalmology and Visual Sciences, Osaka City University, Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Background:
Indocyanine green (ICG) angiography is considered to be an effective clinical tool to detect choroidal neovascularization (CNV) in age-related macular degeneration. However, CNV detection by angiography becomes difficult when a thick hemorrhagic lesion exists.
Methods:
CNV was analyzed in 20 eyes (20 patients) showing age-related macular degeneration and accompanying subretinal hemorrhage using the subtraction method of ICG angiography.
Results:
Subtraction ICG angiography revealed hyperfluorescent areas determined as dye leakage from CNV in all 20 cases. In 6 of the 20 cases, ill-defined fluorescence-increasing areas were observed which expanded during continuing angiography. On the other hand, the remaining 7 cases showed well-defined fluorescence-increasing areas which did not expand over time.
Conclusions:
The subtraction method is an effective clinical tool to detect CNV concomitant with subretinal hemorrhage. Moreover, this method provides information to elucidate an increasing pattern of fluorescence surrounding CNV.
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