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Related Experiment Videos

Androgens and bone.

Dirk Vanderschueren1, Liesbeth Vandenput, Steven Boonen

  • 1Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium.

Endocrine Reviews
|June 8, 2004
PubMed
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Androgens and estrogens are crucial for maintaining bone mass and integrity. Androgens protect men against osteoporosis by preserving bone and expanding cortical bone size, acting through androgen and estrogen receptors.

Area of Science:

  • Endocrinology
  • Bone Biology
  • Osteoporosis Research

Background:

  • Sex hormones, including estrogens and androgens, play a vital role in bone remodeling and maintaining bone mass.
  • Loss of these hormones leads to increased bone remodeling and an imbalance between bone resorption and formation.
  • The specific contributions of androgens and estrogens to bone health, particularly cancellous and cortical bone, are not fully understood.

Purpose of the Study:

  • To elucidate the distinct and overlapping roles of androgens and estrogens in regulating bone mass and integrity.
  • To investigate the mechanisms by which androgens influence cancellous and cortical bone, including the involvement of androgen receptors (AR) and estrogen receptors (ERs).
  • To determine the contribution of androgen aromatization to estrogen and direct androgen action via AR in bone.

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Main Methods:

  • Review of recent studies examining the effects of androgens and estrogens on bone remodeling.
  • Analysis of experimental data, including studies in rodents and mice lacking specific hormone receptors.
  • Investigation of the roles of androgen receptor (AR) and estrogen receptors (ERalpha, ERbeta) in mediating androgen effects on bone.

Main Results:

  • Both androgens and estrogens maintain cancellous bone mass and integrity.
  • Androgens increase cortical bone size through stimulation of longitudinal and radial growth.
  • Androgen action on bone involves both direct AR activation and aromatization to estrogens, with ERalpha playing a key role.

Conclusions:

  • Androgens protect men against osteoporosis by maintaining cancellous bone mass and increasing cortical bone dimensions.
  • Androgen-mediated bone protection involves signaling through both the androgen receptor (AR) and estrogen receptor alpha (ERalpha).
  • Understanding these pathways is crucial for developing targeted therapies for osteoporosis.