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Selective ring-opening carbonylation of epoxy-steroids
Attila Balázs1, Csilla Benedek, Gábor Szalontai
1Department of Organic Chemistry, University of Veszprém, H-8201 Veszprém, P.O. Box 158, Hungary.
Steroids
|June 9, 2004
Abstract:
Ring-opening alkoxycarbonylation of epoxy-steroids has been carried out with a Co2(CO)8/3-hydroxypyridine catalytic system. High chemo- and regioselectivities were obtained under the reaction conditions applied. Structural analysis of the products proved their high stereochemical purity in each case, accompanied by inversion of the original configuration. No carbonylation took place for sterically hindered steranic epoxides.