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Related Experiment Videos

Current treatment options for chronic constipation.

Jack A DiPalma1

  • 1Division of Gastroenterology, University of South Alabama College of Medicine, Mobile, Alabama, USA.

Reviews in Gastroenterological Disorders
|June 9, 2004
PubMed
Summary

This review summarizes treatments for chronic constipation, finding polyethylene glycol safe and effective for initial or later use. Other options include fiber, osmotic laxatives, and stimulants.

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Chronic constipation affects many, yet few treatments are rigorously studied.
  • Various agents like fiber, laxatives, and stimulants are used.

Purpose of the Study:

  • To review available data on medical management of chronic constipation.
  • To evaluate efficacy and safety of different treatment options.

Main Methods:

  • Systematic review of data on bulk agents, lubricants, stimulants, and osmotic laxatives.
  • Analysis of treatments used alone and in combination.

Main Results:

  • Dietary fiber and bulk agents are common initial treatments.
  • Polyethylene glycol demonstrates safety and efficacy as an initial or second-line therapy.
  • Saline osmotic laxatives, lactulose, and stimulants are subsequent options.

Conclusions:

  • A stepwise approach to chronic constipation management is supported by current data.
  • Polyethylene glycol offers a safe and effective option for chronic constipation.
  • Surgery and biofeedback are also considered for specific indications.

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