[Study of neovascularisation in endometrial cancer and hyperplasia using angio-Doppler technique]

The aim of our research work was to evaluate the neovascularisation in endometrial cancer and hyperplasia of the endometrium using "power" angio-Doppler technique. Two hundred and fifty patients /200 bulgarian and 50 patients from Greece/ with irregular bleeding, as well as women without bleeding in menopause were estimated. Age of the patients ranged between 44 and 80 years. There was not found any neovascularisation in the control group patients with normal histopathological results. The sensitivity of our method was 15% for the endometrial hyperplasia and 84% for the endometrial cancer. The specificity and the positive predictive value was for both 100%. For the endometrial cancer p < 0.06/pulsative index--PI--0.95 +/- 14, resistance index--RI--0.45 +/- 0.09, while for the endometrial hyperplasia--PI--1.40 +/- 0.25 and RI--0.65 +/- 0.20. If we summarize our results using "power" angio-Doppler technique the irregular vascularisation of the endometrium in patients with hyperplasia was found in 14%, while for the women with endometrial cancer was 85%. The analysis of the values of blood flow in the neovascularisation areas of the endometrium for level of significance PI < or = 1.0; RI < or = 5 and time-averaged maximum velocity/TAMV/ > 18 cm, may be a very important element in differentiation of benign from malignant lesions. The transvaginal ultrasonography with "power" angio-Doppler technique may serve as an important diagnostic method for differentiation of endometrial hyperplasia from endometrial cancer especially in the early stages of this malignant disease.