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Updated: Feb 7, 2026
Antibiotic Dereplication Using the Antibiotic Resistance Platform
Published on: October 17, 2019
[How to prescribe fewer antibiotics in children?]
1Service de microbiologie, Centre hospitalier intercommunal de Créteil, 94010 Créteil. robert.cohen@wanadoo.fr
Insights
Antibiotic resistance in respiratory pathogens, especially pneumococcus, is rising due to overuse. Coordinated actions including better education, judicious prescribing, and vaccination are crucial for control.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Context:
- Global rise in antibiotic resistance among respiratory tract pathogens.
- Particular concern regarding Streptococcus pneumoniae (pneumococcus).
- Attributed to extensive antibiotic use for respiratory infections and selection pressure.
Purpose:
- To outline coordinated actions to control the alarming increase in antibiotic resistance.
- To emphasize the need for strategic interventions in managing respiratory tract infections.
Summary:
- Improve practitioner education and differentiate viral from bacterial infections.
- Restrict antibiotic use to essential cases, ensuring correct dosage and duration.
- Implement alternative treatments for failures and expedite pneumococcal conjugate vaccine (PCV) use.
Impact:
- Aims to curb the growing threat of antibiotic resistance in respiratory infections.
- Promotes rational antibiotic use and enhances preventative strategies.
- Contributes to preserving the efficacy of antibiotics and reducing pneumococcal disease burden.
Abstract:
During the last years, there has been an alarming worldwide increase in antibiotic resistance among bacterial pathogens of the respiratory tract, and particularly pneumococcus. This is generally attributed to extensive use of antibiotics prescribed for respiratory tract infection and the selection pressure they exert on bacterial strains of nasopharyngeal flora. In our opinion, five actions have to be coordinated in order to control this phenomenon. To improve the continuing education of practitioners and the diagnosis between viral and bacterial respiratory infections, to restrict the use for the situations where antibiotics are really necessary, to prescribe in these situations at the right dosage and duration the more potent antibiotics, to plan straight-a-way an alternative treatment in case of failures, finally achieve a prompt implementation of the pneumococcal conjugate vaccine.
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