Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic changes in receptive-field size in cat primary visual cortex.

M W Pettet1, C D Gilbert

  • 1Rockefeller University, New York, NY 10021-6399.

Proceedings of the National Academy of Sciences of the United States of America
|September 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatio-temporal tuning of coherent motion evoked responses in 4-6 month old infants and adults.

Vision research·2009
Same author

Development of cortical responses to optic flow.

Visual neuroscience·2007
Same author

Fatty acid indices of stearoyl-CoA desaturase do not reflect actual stearoyl-CoA desaturase enzyme activities in adipose tissues of beef steers finished with corn-, flaxseed-, or sorghum-based diets.

Journal of animal science·2005
Same author

Carcass, sensory, and adipose tissue traits of Brangus steers fed casein-formaldehyde-protected starch and/or canola lipid.

Journal of animal science·2003
Same author

Conjugated linoleic acid depresses the delta9 desaturase index and stearoyl coenzyme A desaturase enzyme activity in porcine subcutaneous adipose tissue.

Journal of animal science·2002
Same author

Carcass traits and microsatellite distributions in offspring of sires from three geographical regions of Japan.

Journal of animal science·2002
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Retinal lesions cause visual cortex receptive fields (RFs) to expand by simulating a lack of stimulation. This dynamic RF plasticity may explain visual illusions and cortical reorganization after vision loss.

Area of Science:

  • Neuroscience
  • Visual Neuroscience
  • Cortical Plasticity

Background:

  • Focal retinal lesions lead to rapid expansion of receptive fields (RFs) in the primary visual cortex.
  • This expansion occurs even with limited retinal damage, suggesting a plasticity mechanism beyond photoreceptor loss.

Purpose of the Study:

  • To investigate the role of sensory context in RF expansion after simulated retinal lesions.
  • To determine if RFs in adult animals are dynamically adjustable based on visual input.

Main Methods:

  • Single-cell recordings were performed in cat area 17.
  • An "artificial scotoma" was created by masking visual stimuli within a cell's RF.
  • The effects of masking, direct stimulation, and surrounding visual input on RF size were analyzed.

Related Experiment Videos

Main Results:

  • Simulating an artificial scotoma induced a 5-fold average expansion in RF area within approximately 10 minutes.
  • Stimulating the RF center caused it to contract, while reintroducing the masked stimulus led to reexpansion.
  • RF expansion required stimulation in the surrounding visual field; a blank screen elicited minimal change.

Conclusions:

  • Sensory context, specifically a combination of central visual deprivation and surrounding stimulation, drives RF expansion.
  • This RF plasticity may underlie perceptual phenomena like illusory contours and visual fill-in.
  • These findings highlight the dynamic nature of adult cortical RFs and their susceptibility to alteration by sensory experience.