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Updated: Aug 24, 2026

Electrocardiogram Recordings in Anesthetized Mice using Lead II
Published on: June 20, 2020
[Effect of trimecaine derivatives and lidocaine on hemodynamics]
D S Blinov1, Ia V Kostin, N D Volkova
1Department of Pharmacology, Mordivinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
Abstract:
The results of experiments on cats showed that quaternidine, a quaternary ammonium derivative of trimecaine, does not induce significant variations in the hemodynamic parameters, being advantageous in this respect to some well-known antiarrhythmic drugs. LKhT-3-00 (dialkylaminophenylacetamide glutaminate)--a tertiary derivative of lidocaine--leads to a slight decrease in the heart rate, an insignificant decrease in the arterial pressure for 10 min, and a pronounced enhancement of the pumping ability of the left ventricle over a time period of 30 min.
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