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Related Experiment Videos

Normal pressure hydrocephalus and large head size.

Thomas A Krefft1, Neill R Graff-Radford, John A Lucas

  • 1Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.

Alzheimer Disease and Associated Disorders
|June 16, 2004
PubMed
Summary

Patients diagnosed with normal pressure hydrocephalus (NPH) exhibit larger head circumferences compared to healthy individuals. This finding supports the theory that NPH may stem from congenital hydrocephalus manifesting later in life.

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Area of Science:

  • Neurology
  • Neurosurgery
  • Pediatrics

Background:

  • Previous observations noted larger head sizes in some normal pressure hydrocephalus (NPH) patients.
  • A hypothesis suggested arrested congenital hydrocephalus as a potential cause for NPH presenting later in life.

Purpose of the Study:

  • To investigate whether patients with normal pressure hydrocephalus (NPH) have larger head sizes than control groups.
  • To explore potential links between head size in NPH patients and congenital hydrocephalus.

Main Methods:

  • A cohort of 31 newly diagnosed NPH patients was compared with 459 healthy controls.
  • Head circumference measurements were statistically analyzed between NPH patients and controls, stratified by sex.

Main Results:

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  • NPH patients, both male and female, demonstrated statistically significant larger head circumferences compared to normal controls.
  • The median head size for NPH males was 59.0 cm versus 57.8 cm for normal males (p < 0.01).
  • The median head size for NPH females was 56.3 cm versus 54.6 cm for normal females (p < 0.02).

Conclusions:

  • Patients with normal pressure hydrocephalus (NPH) as a group have larger head circumferences than healthy individuals.
  • The findings suggest that a notable proportion of NPH cases may originate from congenital hydrocephalus that becomes symptomatic in adulthood.
  • This study reinforces the association between enlarged head circumference and NPH, hinting at developmental origins.