Related Experiment Video
Updated: Aug 23, 2026
A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
Sorption of nicotine to cellulose powders
Albert Mihranyan1, Sven-Börje Andersson, Ragnar Ek
1Department of Pharmacy, Uppsala University, P.O. Box 580, Uppsala, SE-751 23, Sweden.
Abstract:
The purpose of this study was to investigate the influence of the crystallinity, surface area, and pore volume of cellulose powders on the loading, release, and stability of nicotine. Four different types of cellulose powders with varying crystallinity index, surface area, and pore volume were produced and characterized. The powders were loaded with nicotine by rotary evaporation from an ethanol solution and by adsorption from nicotine-saturated air. The release of nicotine from loaded cellulose powders into both a passing airstream and water was investigated by UV spectroscopy. A 3-month stability study was conducted and the total sum of nicotine oxidation products was measured. Nicotine loading and release were independent of cellulose powder crystallinity, whereas it was possible to load more nicotine on the cellulose powder with a large surface area and pore volume. Release into water was very rapid and almost complete for all samples. Nicotine was most stable when loaded on the powder with a large surface area and pore volume. Highly porous cellulose matrices could be useful for stabilization and handling of both nicotine and other liquid active pharmaceutical ingredients.
Related Concept Videos
01:23Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
01:16Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...