The 3-D model: does time plasticity represent the influence of tableting speed?
1Martin Luther University Halle-Wittenberg, Institute of Pharmaceutical Technology and Biopharmacy, 06120 Halle/Saale, Germany. picker@pharmazie.uni-halle.de
AAPS Pharmscitech
|June 17, 2004
Summary
Tableting speed significantly impacts time plasticity (parameter d) in pharmaceutical materials like MCC and HPMC. This finding holds true across different tableting machines, validating parameter d
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Chemical Engineering
Background:
- Tablet manufacturing involves complex material deformation processes.
- Understanding the influence of process parameters like tableting speed on material properties is crucial for optimizing tablet quality.
- Three-dimensional (3-D) modeling provides a framework to analyze these complex relationships.
Purpose of the Study:
- To investigate the hypothesis that tableting speed influences time plasticity (parameter d) in pharmaceutical formulations.
- To analyze the effect of tableting speed on material deformation parameters derived from 3-D modeling.
- To validate findings across different tableting machine types.
Main Methods:
- Tablets were manufactured using various materials (dicalcium phosphate dihydrate, lactose, MCC, HPMC, carrageenan, theophylline) at different maximum relative densities.
- Data was collected using an instrumented eccentric tableting machine and a linear rotary tableting machine replicator.
- Heckel analysis and 3-D parameter plots were employed to analyze pressure, normalized time, and porosity data.
Main Results:
- Tableting speed significantly influences time plasticity (parameter d) for plastically and viscoelastically deforming materials (MCC, HPMC, CAR, TheoM).
- Higher densification stages are more affected by tableting speed than lower densification stages.
- Brittle materials (DCPD) and spray-dried lactose showed minimal to no influence of tableting speed on parameter d.
Conclusions:
- The parameter 'd' (time plasticity) in 3-D modeling accurately reflects the influence of time on material behavior during tableting.
- Tableting speed is a critical factor affecting the time plasticity of key pharmaceutical excipients.
- The findings are consistent across both eccentric and linear rotary tableting machine replicator data.
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