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Updated: Aug 23, 2026

High-definition Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
Published on: January 21, 2015
Performance and application of a new planar array infrared spectrograph operating in the mid-infrared (2000-975
Christian Pellerin1, Christopher M Snively, D Bruce Chase
1Department of Materials Science and Engineering, University of Delaware, Newark, Delaware 19716-3106, USA.
Abstract:
A no-moving-part planar array infrared spectrograph (PA-IR) equipped with a 256 x 256 mercury cadmium telluride (MCT) focal plane array has been designed and constructed. The performance of the instrument, whose frequency range extends from 2000-975 cm(-1), has been assessed in terms of resolution, bandwidth, and signal-to-noise ratio. The PA-IR spectrograph is able to record spectra with an 8.7 ms time resolution and has peak-to-peak noise levels as low as 2.4 x 10(-4) A.U. As a demonstration of the potential of PA-IR, the dynamics of reorientation of a liquid crystalline sample exposed to a single electric field pulse has been studied. It was shown that PA-IR can be used for the simultaneous acquisition of two orthogonally polarized spectra. The advantages and limitations of PA-IR, step-scan Fourier transform infrared (FT-IR), and ultrarapid-scanning FT-IR for real-time studies of reversible and irreversible phenomena are thoroughly discussed.
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