Related Experiment Video
Updated: Aug 23, 2026

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
Published on: December 9, 2010
Synthetic studies on macroviracin A: a rapid construction of C(42) macrocyclic dilactone corresponding to the core
Shunya Takahashi1, Kazunori Souma, Ruri Hashimoto
1RIKEN (The Institute of Physical and Chemical Research), Wako-shi, Saitama 351-0198, Japan. shunyat@riken.go.jp
Abstract:
The C(2)-symmetric macrodiolide core 2 of an antiviral agent, macroviracin A (1), was constructed in a single step by the intermolecular macrodimerization of C(22)-hydroxy carboxylic acid 3 with 2-chloro-1,3-dimethylimidazolinium chloride and DMAP in the presence of sodium hydride (NaH). The use of potassium hydride instead of NaH caused the intramolecular cyclization, predominantly providing the corresponding monomer 26. The acid 3 was synthesized through a series of reactions such as the coupling reaction of acetylene 5 and oxirane 6, stereoselective glycosidation with the trichloroacetimidate method, and Jones oxidation.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
ATP and Macromolecule Synthesis
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
Antiviral Nucleoside Inhibitors
Inhibitors of Viral Protein Synthesis
Inhibitors of Bacterial Protein Synthesis
Biosynthesis of Nucleic Acids

