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Transcriptional regulation of interleukin 2 in SLE T cells

Klaus Tenbrock1, George C Tsokos

  • 1Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

International Reviews of Immunology
|June 19, 2004
PubMed

Interleukin-2 (IL-2) is a central cytokine required for the activation of T, B, and NK cells. It propagates the immune response and terminates it by promoting the activation induced cell death of T cells. IL-2 production is altered in T cells of patients with systemic lupus erythematosus (SLE). The consequence of reduced IL-2 production in SLE is decreased immune response to infectious agents. Decreased IL-2 production by SLE T cells is the result of transcriptional repression of the IL-2 gene. This article will review the defective transcription regulation of IL-2 in SLE T cells, which is the result of decreased expression of the enhancers NF-kappa B and AP1 and the increased expression of the transcriptional repressor CREM.

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