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Retrograde Perfusion and Filling of Mouse Coronary Vasculature as Preparation for Micro Computed Tomography Imaging
Published on: February 10, 2012
[Invasive angiography, computed tomography or magnetic resonance imaging for coronary imaging and cardiovascular risk
1Département de pathologie cardiaque, institut Mutualiste-Montsouris, 42, boulevard Jourdan, 75116 Paris, France.
Insights
Coronary heart disease risk stratification is evolving beyond invasive angiography. Noninvasive tools like CT and MR angiography offer valuable insights into atherosclerotic disease, aiding in identifying high-risk patients.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Coronary heart disease risk stratification traditionally relies on invasive coronary angiography.
- This method, while a gold standard, has limitations and is being complemented by newer imaging techniques.
Purpose of the Study:
- To compare the emerging roles of computed tomography (CT) and magnetic resonance (MR) angiography in coronary artery disease assessment.
- To highlight the potential of noninvasive imaging in identifying high-risk cardiovascular patients.
Main Methods:
- Review of current practices in coronary heart disease risk stratification.
- Discussion of the capabilities and challenges of coronary CT angiography and MR angiography.
Main Results:
- Multidetector-row and multisclice spiral CT angiography show high value in detecting coronary artery disease, particularly in proximal branches.
- CT and MR angiography can identify flow-limiting stenoses, calcified plaques, and characterize atherosclerotic lesions, providing predictive cardiovascular risk information.
Conclusions:
- Noninvasive imaging with CT and MR angiography offers complementary information to traditional methods for cardiovascular risk assessment.
- The ultimate goal is to integrate imaging with other strategies to identify high-risk patients for personalized treatment.
Abstract:
In 2003, risk stratification in coronary heart disease is routinely performed by the results of coronary angiogram, the invasive gold standard angiography. Combined with the left ventricular ejection fraction assessment, the classification in one, two or three vessel disease remain the cornerstone of the revascularization strategy despite well-known limitations of this approach. Invasive coronary angiography is a mature technic with recommendations for training program and guidelines for indications. By comparison, the new noninvasive coronary imaging tools, computed tomography (CT) and magnetic resonance (MR) imaging, are just emerging. Coronary artery MR angiography is one of the most challenging areas because of the size and topology of the coronary arteries, as well as cardiac and respiratory motion. Multidetector-row and multisclice spiral computed tomography appear of most value for the detection of coronary artery disease with an excellent negative predictive value for proximal and middle main branches. Together, MR and CT, provide unique information that may predict cardiovascular risk. They identify flow-limiting coronary stenoses and calcified plaques, directly image the atherosclerotic lesions, measure atherosclerotic burden and characterize plaque components. Nevertheless, invasive coronary angiography still remain the first step of percutaneous coronary intervention. Therefore, one of the ultimate goals for the clinicians is the identification of the high-risk patient through a combination of strategies such as assessment of conventional risk factors, blood markers, and imaging. Indifferently to the imaging tool, the treatment should consider a human being and not only a picture.
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