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Updated: Aug 23, 2026

Investigating the Three-dimensional Flow Separation Induced by a Model Vocal Fold Polyp
Published on: February 3, 2014
[Roles of CD45RO, CD20 and local IgE in the pathogenesis of vocal fold polyps]
Hongming Gao1, Zhengqiang Wang, Mingxiu Zheng
1Department of Otorhinolaryngology, Second Clinical Hospital, Kunming Medical College, Kunming, 650031, China.
Objective:
To investigate the roles of CD45RO, CD20 and local IgE in the pathogenesis of vocal fold polyps.
Method:
Thirty cases of vocal fold polyps and ten cases of normal vocal folds were used in present study by immunohistochemical method to detect the CD45RO, CD20 and IgE cells. A mean numbers of positive cells per high power field(X 400) were counted. All data were analyzed with t-test and correl-test by SPSS10.0 software.
Result:
The number of CD45RO+ cells, CD20+ cells and local IgE cells in vocal fold polyps was significantly more than in normal vocal folds (P < 0.01). The expression of CD45RO+ cells, CD20+ cells and local IgE+ cells in vocal fold polyps was no connection relations. The expression of CD45RO+ cells, CD20+ cells and local IgE cells between male and female vocal fold polyps was no significant(P > 0.05).
Conclusion:
There were active cellular immunity and humoral immunity in vocal fold polyps. Local allergy may play a role in the pathogenesis of vocal fold polyps.
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