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Spectrum of anti-measles immunoglobulin G subclasses in convalescents after measles
A P Toptygina1, A L Pukhal'skii, T A Mamaeva
1G. N. Gabrichevskii Moscow Institute of Epidemiology and Microbiology, Moscow. toptyginaanna@km.ru
Abstract:
A simple semiquantitative method for measuring anti-measles IgG subclasses is developed on the basis of commercial diagnostic test system for measurements of anti-measles IgG and a kit of peroxidase-labeled monoclonal antibodies to human IgG subclasses. During the acute phase of the disease specific antibodies are presented mainly by IgG2 antibodies, while in subjects with a history of measles more than 10 years before 2 subgroups were detected, which responded by production of IgG2 or IgG1 subclasses.
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