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The Drosophila phenotype gap - and how to close it
1Division of Molecular Genetics, Institute of Biomedical and Life Sciences, University of Glasgow, UK. j.a.t.dow@bio.gla.ac.uk
Briefings in Functional Genomics & Proteomics
|July 9, 2004
Summary
Functional genomics requires more functional biology input from genetic model organisms. Analyzing genome annotations reveals a "phenotype gap," highlighting a need for increased physiological studies in organisms like Drosophila.
Area of Science:
- Genomics
- Functional Biology
- Physiology
Background:
- Functional genomics, which elucidates gene function within a sequenced genome, heavily relies on functional biology.
- Genetic model organisms have historically received limited physiological research input.
- This disparity creates a 'phenotype gap' impacting the progress of post-genomic research.
Purpose of the Study:
- To quantify the 'phenotype gap' in functional genomics research.
- To assess the current skills base in relation to post-genomic research needs.
- To identify necessary shifts in research focus for model organisms like Drosophila.
Main Methods:
- Analysis of sequenced genome annotations.
- Quantification of the 'phenotype gap' through annotation data.
- Case study using Drosophila melanogaster.
Main Results:
- The study quantifies a significant 'phenotype gap' in functional genomics.
- Genome annotation analysis reveals a lack of physiological data for model organisms.
- Drosophila research shows a historical bias towards developmental biology.
Conclusions:
- A skills mismatch exists between functional genomics needs and the physiological input for model organisms.
- Addressing the 'phenotype gap' requires a shift towards transport physiology and metabolism research.
- A more balanced skills base is crucial for advancing post-genomic research, particularly in Drosophila.
