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Nucleotide sequence of a cDNA encoding murine fumarylacetoacetate hydrolase
1Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201.
Biochemical Medicine and Metabolic Biology
|August 1, 1992
Abstract:
Hereditary tyrosinemia type I is caused by deficiency of the enzyme fumarylacetoacetate hydrolase (FAH) (EC 3.7.1.2), the final step in tyrosine degradation. We report here the cloning and sequencing of a full length cDNA coding for murine FAH. This cDNA is highly homologous to the previously cloned human and rat genes.