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Published on: October 12, 2012
[Fixed drug eruption induced by sulfaguanidine]
S Kastalli1, S El Aidli, R Daghfous
1Centre National de Pharmacovigilance, Hôpital Charles Nicolle, Boulevard du 9 avril 1938, Tunis 1006, Tunisie.
Introduction:
Fixed drug eruption is a lesion induced by drugs. The family of drugs usually incriminated are sulfonamides, tetracyclines and pyrazols. We describe nine cases of fixed drug eruption induced by sulfaguanidine, a sulfonamide with local action.
Case Reports:
All the patients presented one or more fixed drug eruption reactivation lesions induced by sulfaguanidine as self-medication for diarrhea. The number of lesions increased in 7 cases after reactivation. The delay in occurrence of the fixed drug eruption decreased during the different episodes. The lesions predominated on the hands in 8 cases of 9.
Discussion:
The sulfaguanidine must be added to the list of drug-induced fixed drug eruptions with limited absorption from the gastrointestinal tract.
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