Accurate sensitivity in optically preamplified direct detection

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Infrared Degenerate Four-wave Mixing with Upconversion Detection for Quantitative Gas Sensing
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Paolo Martelli1, Silvia M Pietralunga, Dario Nicodemi

  • 1CoreCom, Via G. Colombo 81, 20133 Milan, Italy. martelli@corecom.it

Optics Letters
|July 21, 2004
PubMed

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Difference from Background: Limit of Detection01:05

Difference from Background: Limit of Detection

The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
The LOD indicates the presence or absence...