Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eph receptors, ephrins, and synaptic function.

Keith K Murai1, Elena B Pasquale

  • 1Centre for Research in Neuroscience, McGill University Health Centre, Montreal General Hospital, Montreal, Canada.

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|July 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role" [BBA Mol. Cell Res. 1873 (2026) 120081].

Biochimica et biophysica acta. Molecular cell research·2026
Same author

Automation of high-throughput workflow for arrayed CRISPR activation library screening.

bioRxiv : the preprint server for biology·2025
Same author

Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor role.

Biochimica et biophysica acta. Molecular cell research·2025
Same author

Distribution and morphological features of astrocytes and Purkinje cells in the human cerebellum.

Frontiers in neuroanatomy·2025
Same author

Single-cell omics and heterogeneity of neuroglial cells.

Handbook of clinical neurology·2025
Same author

An Astrocyte Transplantation Method to Investigate Astrocyte Development and Diversity in the Central Nervous System (CNS).

Methods in molecular biology (Clifton, N.J.)·2025
Same journal

Nonclustered Protocadherins in Autism: Integrating Cell Adhesion and Activity-Dependent Signalling.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

Brain-on-a-Chip and Blood-Brain Barrier-on-a-Chip Modeling for Neurodegenerative Disorders: Recent Progress.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

The Left Ventral Premotor Cortex: Powerful Roles in Reading.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

The 3-Body Problem: How Astrocytes May Govern Plasticity.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

Perisynaptic Astrocytic Processes as Communication Hubs and Early Sites of Dysfunction.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
Same journal

Heat Shock Proteins in Schizophrenia: Integrating Stress Responses, Molecular Pathways, and Emerging Therapeutic Strategies.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry·2026
See all related articles

Eph receptors and ephrin ligands are crucial for developing excitatory synapses in the central nervous system. These cell surface proteins regulate synaptic function, including N-methyl-D-aspartate receptor activity and memory formation.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Background:

  • Receptor tyrosine kinases of the Eph family and their ephrin ligands are cell surface proteins involved in cell-cell communication.
  • Synapses are critical for neuronal communication and information processing in the central nervous system.

Purpose of the Study:

  • To review the role of Eph receptors and ephrins in the development and function of excitatory synapses.
  • To discuss the integration of Eph-ephrin signaling into the molecular machinery of synaptic function.

Main Methods:

  • Literature review of existing research on Eph receptors, ephrins, and synaptic function.
  • Analysis of studies investigating the molecular mechanisms underlying Eph-ephrin involvement in synaptic properties.

Related Experiment Videos

Main Results:

  • Eph receptors and ephrins are essential for regulating the properties of developing mature excitatory synapses.
  • These proteins modulate N-methyl-D-aspartate receptor clustering and function.
  • Eph-ephrin signaling influences postsynaptic terminal geometry, synaptic plasticity, and memory.

Conclusions:

  • Eph receptors and ephrins are key regulators of excitatory synapse development and function.
  • Their bidirectional signaling at cell-cell contacts is vital for synaptic plasticity and memory.
  • Understanding Eph-ephrin integration offers insights into the molecular basis of synaptic function.