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First and second generations of COX-2 selective inhibitors
Xavier de Leval1, Fabien Julémont, Valérie Benoit
1Natural and Synthetic Drugs Research Centre, Laboratory of Medicinal Chemistry, University of Liège, 1 av. de l'Hôpital, tour 4(+5) Sart-Tilman, B-4000 Liège, Belgium. xdeleval@ulg.ac.be
Mini Reviews in Medicinal Chemistry
|July 29, 2004
Abstract:
The identification and characterization of the inducible form of cyclooxygenases (COX-2) stimulated the investigations to develop efficient, non-steroidal anti-inflammatory drugs (NSAIDs) with reduced side effects (essentially gastro-intestinal toxicity) compared to classical NSAIDs. This review focuses on the chemical and pharmacological properties (pre-clinical data) of marketed COX-2 inhibitors.