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Extrinsic neural contribution to ileal peptide YY (PYY) release
M Rudnicki1, B W Kuvshinoff, D W McFadden
1Department of Surgery, Mary Imogene Bassett Hospital, Cooperstown, New York.
The Journal of Surgical Research
|June 1, 1992
Summary
Extrinsic neural pathways regulate Peptide YY (PYY) release into the ileal lumen. Surgical denervation of ileal loops reduced PYY recovery after cholecystokinin (CCK) and glucose stimulation, confirming neural involvement.
Area of Science:
- Gastroenterology
- Neuroendocrinology
- Physiology
Background:
- Peptide YY (PYY) release is stimulated by cholecystokinin (CCK) and glucose.
- Vagal activity is implicated in PYY release into circulation and the ileal lumen.
Purpose of the Study:
- To evaluate extrinsic neural involvement in CCK and glucose-stimulated PYY release.
- To investigate the role of extrinsic neural pathways in mediating ileal PYY release.
Main Methods:
- Created distal ileal Thiry-Vella loops (TVL) in dogs.
- Administered intravenous CCK or oral glucose tolerance tests (OGTT).
- Collected peripheral blood and ileal effusate samples before and after stimulation, with and without TVL denervation.
Main Results:
- OGTT significantly increased ileal PYY recovery but not circulating PYY.
- Intravenous CCK significantly increased both plasma and ileal PYY.
- TVL denervation reduced ileal PYY recovery after CCK and OGTT, without affecting circulating PYY.
Conclusions:
- Extrinsic neural pathways are crucial for mediating CCK- and glucose-stimulated ileal PYY release.
- Denervation of ileal loops inhibits stimulated PYY recovery, highlighting the role of neural signaling.