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Updated: Aug 23, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Virus subversion of protective immunity
Eric W Hewitt1, Gillian E Dugan
1School of Biochemistry and Microbiology, University of Leeds, Leeds, LS2 9JT, UK. e.w.hewitt@leeds.ac.uk
Abstract:
The major histocompatibility (MHC) class I antigen presentation pathway plays a pivotal role in immunity to viruses. MHC class I molecules are expressed on the cell surface of all nucleated cells and present peptides derived from intracellular proteins to cytotoxic T lymphocytes (CTLs), which then eliminate virally infected cells. However, many viruses have evolved proteins to inhibit the MHC class I pathway, thus enabling virally infected cells to escape CTL lysis. In this review, we summarize recent findings about viral inhibition of the MHC class I pathway.
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