Keratoacanthoma ensuing from bone marrow transplantation for chronic myeloid leukemia

We encountered a 36-year-old woman, who developed two keratoacanthomas at rather a short interval after bone marrow transplantation for chronic myeloid leukemia. This skin disease seems to be associated with various factors, but its etiology still remains obscure. The fact that the patient was under postoperative immunosuppressive treatment suggests that, among other factors, a deterioration or an impairment of immunocapacity may play some role in the pathogenesis of keratoacanthoma. It is intriguing that two lesions appeared successively in one patient.