Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Skin deep.

Jonathan Hadgraft1

  • 1Medway Sciences, University of Greenwich, Kent, UK. johnathan.hadgraft@btinternet.com

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|August 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial to "Memorial issue for Dr Kenneth A Walters".

International journal of pharmaceutics·2022
Same author

A preliminary investigation into the use of amino acids as potential ion pairs for diclofenac transdermal delivery.

International journal of pharmaceutics·2022
Same author

Thermal analysis of mammalian stratum corneum using differential scanning calorimetry for advancing skin research and drug delivery.

International journal of pharmaceutics·2022
Same author

Ion Pairs for Transdermal and Dermal Drug Delivery: A Review.

Pharmaceutics·2021
Same author

Dermal Delivery of Niacinamide-In Vivo Studies.

Pharmaceutics·2021
Same author

Dermal delivery of amitriptyline for topical analgesia.

Drug delivery and translational research·2021
Same journal

Partition-controlled drug release from polymeric nanocapsules: A physically consistent framework with formulation-specific corrections.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Formulation-dependent differences in systemic glutathione availability: Comparative pharmacokinetics of orally dissolving film and tablet formulations in healthy adults.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Does magnesium permeate the skin? An ex vivo investigation of magnesium ion delivery through intact and barrier-disrupted skin.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Surface engineering of graphene as a novel nano-carrier for doxorubicin using sugar-based deep eutectic systems.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Buprenorphine long acting injectables: clinical needs, pharmacodynamic and pharmacokinetic basis, and design challenges for solid preformed implants.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same journal

Design rules for externally triggered drug uncaging under optical and radiolytic regimes.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
See all related articles

Advances in biophysical techniques and computing power have improved understanding of skin permeation mechanisms. Mathematical models now predict percutaneous penetration and transdermal delivery, aiding enhancer strategy development.

Area of Science:

  • Pharmacology
  • Biophysics
  • Materials Science

Background:

  • Significant progress in understanding skin permeation mechanisms over the last 30 years.
  • Advancements driven by sophisticated biophysical techniques and increased computational power.
  • Molecular-level insights into permeation routes and barrier function modulation by formulation excipients.

Purpose of the Study:

  • Review advances in skin permeation knowledge.
  • Discuss mathematical models for predicting percutaneous penetration and transdermal delivery.
  • Explore enhancement strategies for dermal penetration.

Main Methods:

  • Utilizing sophisticated biophysical techniques.
  • Developing and applying mathematical models for prediction.

Related Experiment Videos

  • Employing chemometric analysis in conjunction with biophysical data and modeling.

    • Main Results:

    • Enhanced understanding of molecular mechanisms of skin permeation.
    • Development of predictive models for percutaneous penetration and transdermal delivery.
    • Identification of various dermal penetration enhancement strategies.

    Conclusions:

    • Biophysical techniques, mathematical modeling, and chemometric analysis can elucidate enhancer mechanisms.
    • Models aid in identifying rate-controlling factors in transdermal delivery, whether in the device or skin.