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Updated: Aug 23, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
On the application of phase relationships to complex structures. XXXV. Some experiments with 2-Zn insulin
1Department of Solid Physics, Indian Association for the Cultivation of Science, Jadavpur, Calcutta, India.
Abstract:
The direct-methods program SAYTAN has been applied to the known structure of 2-Zn insulin with 806 atoms, excluding solvent, in the asymmetric unit. Useful sets of phases can be obtained and selected by figures of merit for data resolutions between 1.5 and 2.25 A and these can be extended by SAYTAN to give mean phase errors of 68 degrees for more than 2000 reflections. A feature of the phases so found is that the phase errors decrease with increasing resolution - which is the opposite of the situation when phases are found by isomorphous-replacement techniques.
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