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Azithromycin and warfarin interaction.

Sarah P Shrader1, Joli D Fermo, Amy L Dzikowski

  • 1Department of Pharmacy and Clinical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

Pharmacotherapy
|August 12, 2004
PubMed
Summary
This summary is machine-generated.

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This case study highlights a potential drug interaction between azithromycin and warfarin. Even with reduced confounding factors, azithromycin may increase warfarin

Area of Science:

  • Pharmacology
  • Clinical Medicine

Background:

  • The co-administration of azithromycin and warfarin, a common antibiotic and anticoagulant, raises concerns due to potential interactions.
  • Previous case reports suggest an azithromycin-warfarin interaction, but often involved multiple confounding variables.
  • The absence of this interaction in many drug references and package inserts necessitates further investigation.

Observation:

  • A 57-year-old woman on warfarin experienced a significantly elevated International Normalized Ratio (INR) of 8.32 after a course of azithromycin.
  • The patient had minimal confounding factors, primarily a reduction in smoking, during the azithromycin treatment.
  • This case presents a scenario with a single potential confounding variable, unlike previous reports.

Findings:

  • The observed elevated INR suggests a possible interaction between azithromycin and warfarin, leading to increased anticoagulant effect.

Related Experiment Videos

  • This interaction occurred despite the patient's reduced smoking, a factor often considered in warfarin management.
  • The case adds to the limited but important documentation of azithromycin-warfarin interactions.

    • Implications:

    • Clinicians should exercise caution when prescribing azithromycin to patients concurrently taking warfarin.
    • Regular monitoring of INR is crucial in patients receiving both azithromycin and warfarin.
    • Further research and documentation are needed to fully elucidate the azithromycin-warfarin interaction due to its clinical significance and widespread drug use.