[Evaluation of telomerase activation in laryngeal mucosa adjacent to carcinoma]
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Published on: March 11, 2014
Ming Chen1, Beibei Yang, Xing Zhang
1Department of Otolaryngology, Second Affiliated Hospital of Medical School, Zhejiang University, Hangzhou, 310009, China.
Objective:
To investigate telomerase activity in laryngeal nonmalignant mucosa adjacent to carcinoma and discuss its effect on extension and recurrence of laryngeal carcinoma.
Method:
Telomerase repeat amplification protocol was used and combined with histological examination.
Result:
The positive percentage of telomerase activation was even higher in laryngeal nonmalignant mucosa distant toward surgically negative margin of carcinoma than in laryngeal carcinomas themselves (P<0.05).
Conclusion:
Telomerase activation occurred probably before the morphologic alteration, which may imply expansion of the cells with potential of malignant transformation.
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