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Endothelium-dependent vasodilation during acute rejection in dogs

Paul J Pearson1, Chi-Ming Wei, Pyng J Lin

  • 1Division of Cardiovascular Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Summary

Acute rejection after heart transplant involves increased endothelin, a vasoconstrictor, not impaired coronary artery vasodilation. This suggests endothelin contributes to graft dysfunction in early stages.

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