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Fat adherence syndrome: an animal model.

Natalie C Kerr1

  • 1Department of Ophthalmology, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA. nkerr@utmem.edu

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|August 18, 2004
PubMed
Summary

Fat autografts in rabbit eyes caused permanent restrictive strabismus, a condition known as fat adherence syndrome (FAS). This animal model may help researchers study FAS pathophysiology.

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Area of Science:

  • Ophthalmology
  • Surgical Research
  • Animal Models

Background:

  • Fat adherence syndrome (FAS) is a persistent restrictive strabismus.
  • It can arise after eye surgery or trauma.
  • The underlying causes of FAS are not well understood.

Purpose of the Study:

  • To investigate the pathophysiology of fat adherence syndrome (FAS).
  • To establish a rabbit model for studying FAS.

Main Methods:

  • Fat autografts were surgically placed in rabbit eyes, secured with dissolvable sutures.
  • Force measurements assessed eye movement restriction before and after surgery.
  • Rabbits were observed for 6 weeks and 6 months post-surgery.

Main Results:

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  • Post-surgery, significant eye movement restriction was observed compared to baseline.
  • The degree of orbital fat influenced the resulting eye stiffness.
  • Strabismus remained stable over 6 months and was not resolved by adhesion lysis or graft removal.

Conclusions:

  • Introducing fat autografts into extraocular wounds in rabbits induces permanent restrictive strabismus.
  • This rabbit model shows promise for future research into fat adherence syndrome.