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An association study of PCQAP polymorphisms and schizophrenia
Harinder K Sandhu1, Nancy Hollenbeck, Thomas H Wassink
1Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242-1000, USA.
Psychiatric Genetics
|August 20, 2004
Summary
Polymorphisms in the PCQAP gene exon 7 were investigated for association with schizophrenia. This study found no significant differences in CAG repeat alleles between schizophrenia patients and controls, limiting the gene's role in the disorder.
Area of Science:
- Genetics
- Neuroscience
- Psychiatry
Background:
- PCQAP, a mediator complex gene, is located in the 22q11 region deleted in DiGeorge/velocardiofacial syndrome.
- DiGeorge/velocardiofacial syndrome is linked to psychosis and neurodevelopmental abnormalities.
- Previous studies suggested a link between PCQAP exon 7 polymorphisms and schizophrenia.
Purpose of the Study:
- To confirm and extend prior findings on the association between PCQAP exon 7 polymorphisms and schizophrenia.
- To investigate the role of PCQAP gene variations in schizophrenia pathogenesis.
Main Methods:
- A case-control association analysis was performed.
- DNA samples from 233 schizophrenia patients and 371 controls were analyzed.
- Distribution of trinucleotide repeat (CAG) alleles in PCQAP exon 7 was compared between groups.
Main Results:
- No significant differences were observed in the distribution of CAG repeat alleles between schizophrenia subjects and control individuals.
- The findings did not support an association between PCQAP exon 7 polymorphisms and schizophrenia in the studied population.
Conclusions:
- The results suggest that polymorphisms in PCQAP exon 7 do not play a significant role in the pathogenesis of schizophrenia.
- Further research may be needed to explore other genetic factors contributing to schizophrenia.