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Published on: November 16, 2016
Emerging gram-positive bacterial infections
Sameer Elsayed1, Kevin B Laupland
1Department of Pathology and Laboratory Medicine, University of Calgary, 9, 3535 Research Road NW, Calgary, Alberta T2L 2K8, Canada. sameer.elsayed@cls.ab.ca
Abstract:
Over the last several decades, a number of previously known or newly described species of gram-positive bacteria have emerged as important human pathogens, particularly in industrialized countries. These microbes have demonstrated an impressive ability to produce an array of striking infectious diseases never before seen or only infrequently encountered in the past. Despite aggressive therapeutic intervention, many of these conditions portend significant morbidity and mortality. Diseases caused by members of the Staphylococcus and Streptococcus genera have figured prominently in this regard, with Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes, and other beta-hemolytic streptococci being regarded as the most important species. This review focuses on the clinical and microbiologic aspects of key emerging infections caused by this group of microorganisms.
Insights
Emerging gram-positive bacterial infections, particularly from Staphylococcus and Streptococcus species, are causing significant human disease and mortality. This review examines key clinical and microbiologic aspects of these important emerging pathogens.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Medicine
Background:
- Gram-positive bacteria, including Staphylococcus and Streptococcus species, have increasingly emerged as significant human pathogens.
- These microbes are associated with novel or rarely seen infectious diseases, particularly in industrialized nations.
- Many of these infections lead to substantial morbidity and mortality despite treatment.
Purpose of the Study:
- To review the clinical and microbiologic characteristics of key emerging gram-positive bacterial infections.
- To highlight the significance of Staphylococcus aureus, S. epidermidis, Streptococcus pyogenes, and beta-hemolytic streptococci as emerging pathogens.
Main Methods:
- This is a review article.
- Focuses on clinical and microbiologic aspects.
- Synthesizes information on emerging gram-positive infections.
Main Results:
- Staphylococcus and Streptococcus species are prominent causes of emerging infectious diseases.
- Specific species like Staphylococcus aureus, S. epidermidis, and Streptococcus pyogenes are of major concern.
- These infections present unique clinical challenges and significant health risks.
Conclusions:
- Emerging gram-positive bacterial infections pose a serious threat to public health.
- Understanding the clinical and microbiologic features of these pathogens is crucial for effective management.
- Continued research and surveillance are necessary to combat these evolving infectious diseases.
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