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Emerging fungal resistance

John W Baddley1, Stephen A Moser

  • 1Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, 1900 University Boulevard, 229 Tinsley Harrison Tower, Birmingham, AL 35294, USA.

Clinics in Laboratory Medicine
|August 25, 2004
PubMed

Insights

Systemic fungal infections are rising, alongside azole-resistant Candida and molds. This review highlights emerging antifungal resistance patterns and inherently resistant fungi.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Increasing incidence of systemic fungal infections globally.
  • Rise in critically ill patients, invasive procedures, and immunosuppressive therapies contributing to infection risk.
  • Growing prevalence of azole-resistant Candida species and intrinsically resistant opportunistic molds.

Purpose of the Study:

  • To review current trends in antifungal resistance.
  • To emphasize emerging resistance patterns in fungal pathogens.
  • To discuss newly identified fungi with intrinsic antifungal resistance.

Main Methods:

  • Literature review of recent studies on antifungal resistance.
  • Analysis of epidemiological data on fungal infections.
  • Examination of mechanisms of azole resistance and intrinsic fungal resistance.

Main Results:

  • Significant increase in systemic fungal infections over recent decades.
  • Documented rise in antifungal resistance, particularly azole resistance in Candida.
  • Identification of emerging opportunistic molds with inherent resistance to standard antifungals.

Conclusions:

  • Antifungal resistance poses a growing threat in clinical settings.
  • Emerging resistance patterns necessitate updated treatment strategies.
  • Further research is crucial to combat intrinsically resistant fungal infections.

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