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Emerging fungal resistance.
John W Baddley1, Stephen A Moser
1Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, 1900 University Boulevard, 229 Tinsley Harrison Tower, Birmingham, AL 35294, USA.
Clinics in Laboratory Medicine
|August 25, 2004
Summary
Systemic fungal infections are rising, alongside azole-resistant Candida and molds. This review highlights emerging antifungal resistance patterns and inherently resistant fungi.
Area of Science:
- Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Increasing incidence of systemic fungal infections globally.
- Rise in critically ill patients, invasive procedures, and immunosuppressive therapies contributing to infection risk.
- Growing prevalence of azole-resistant Candida species and intrinsically resistant opportunistic molds.
Purpose of the Study:
- To review current trends in antifungal resistance.
- To emphasize emerging resistance patterns in fungal pathogens.
- To discuss newly identified fungi with intrinsic antifungal resistance.
Main Methods:
- Literature review of recent studies on antifungal resistance.
- Analysis of epidemiological data on fungal infections.
- Examination of mechanisms of azole resistance and intrinsic fungal resistance.
Main Results:
- Significant increase in systemic fungal infections over recent decades.
- Documented rise in antifungal resistance, particularly azole resistance in Candida.
- Identification of emerging opportunistic molds with inherent resistance to standard antifungals.
Conclusions:
- Antifungal resistance poses a growing threat in clinical settings.
- Emerging resistance patterns necessitate updated treatment strategies.
- Further research is crucial to combat intrinsically resistant fungal infections.