Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The albumin controversy.

Michael R Uhing1

  • 1Division of Neonatology, Medical College of Wisconsin, Neonatal Intensive Care Unit, Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. mushing@mcw.edu

Clinics in Perinatology
|August 25, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Pilot Randomized Controlled Trial of Outcomes Associated with Parent-Nurse Controlled Analgesia vs. Continuous Opioid Infusion in the Neonatal Intensive Care Unit.

Pain management nursing : official journal of the American Society of Pain Management Nurses·2019
Same author

Anesthetic Management of an Infant With Postnatally Diagnosed Tracheal Agenesis Undergoing Tracheal Reconstruction: A Case Report.

A & A case reports·2017
Same author

Outcomes of Infants With Home Tube Feeding: Comparing Nasogastric vs Gastrostomy Tubes.

JPEN. Journal of parenteral and enteral nutrition·2016
Same author

Maternal opioid dose is associated with neonatal abstinence syndrome in children born to women with sickle cell disease.

American journal of hematology·2016
Same author

Migration of Central Venous Catheters in Neonates: A Radiographic Assessment.

American journal of perinatology·2016
Same author

Role of admission gas exchange measurement in predicting congenital diaphragmatic hernia survival in the era of gentle ventilation.

Journal of pediatric surgery·2014
Same journal

Breathing Physiology into the Art of Neonatal Respiratory Care.

Clinics in perinatology·2026
Same journal

The Science and Art of Neonatal Respiratory Care.

Clinics in perinatology·2026
Same journal

Ex Utero Artificial Womb Support: Promising Future for Extremely Preterm Infants.

Clinics in perinatology·2026
Same journal

Advances in the Use of Cell-Based Therapies for Prevention of Bronchopulmonary Dysplasia.

Clinics in perinatology·2026
Same journal

Evaluation and Management of Genetic Respiratory Disorders Presenting as Hypoxemic Respiratory Failure in the Newborn Infant.

Clinics in perinatology·2026
Same journal

Modern Surfactant Delivery Methods with a Focus on Implementation of Surfactant Administration Through Laryngeal and Supraglottic Airways.

Clinics in perinatology·2026
See all related articles

Albumin use in neonates and children offers limited benefits over crystalloids. Albumin is rarely indicated in the neonatal ICU, except for specific hypovolemia cases after crystalloid failure.

Area of Science:

  • Pediatric Critical Care Medicine
  • Neonatology
  • Pharmacology

Background:

  • Limited research exists on albumin use in pediatric populations.
  • Existing studies show inconsistent benefits of albumin compared to crystalloid solutions.

Purpose of the Study:

  • To review the current evidence regarding albumin administration in neonates and children.
  • To define appropriate indications for albumin use in pediatric intensive care settings.

Main Methods:

  • Systematic review of existing literature on albumin use in pediatric patients.
  • Analysis of studies comparing albumin with crystalloid solutions and other interventions.

Main Results:

  • Albumin is not indicated for isolated hypoalbuminemia, neonatal hypotension, respiratory distress, or partial exchange transfusions.

Related Experiment Videos

  • In adults, albumin is not first-line therapy for hypovolemia, burns, or nutritional support.
  • Albumin may be considered for hypovolemia post-crystalloid failure, hemorrhagic shock (if blood products unavailable), or significant albumin loss with normal capillary function.

    • Conclusions:

    • Albumin should be used sparingly in the neonatal intensive care unit (NICU).
    • Its use in conditions with increased capillary permeability may worsen edema without improving outcomes.
    • Long-term benefits are typically not demonstrated, and patients often recover regardless of albumin administration.