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Updated: Aug 22, 2026

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
Published on: May 16, 2015
Fomepizole alone for severe infant ethylene glycol poisoning
Thierry Detaille1, Pierre Wallemacq, Stephan Clément de Cléty
1Pediatric Intensive Care Unit, St-Luc Hospital, Université catholique de Louvain, Brussels, Belgium.
Objective:
To report a case of a massive ingestion of ethylene glycol in an infant successfully treated by fomepizole without hemodialysis.
Design:
Descriptive case report.
Setting:
Pediatric intensive care unit.
Patient:
A 5-mo-old boy who ingested 200 mL of an antifreeze solution.
Interventions:
Antidotal therapy with a total of seven doses of fomepizole administered intravenously with an interval of 12 hrs (15 mg/kg as loading dose, then 10 mg/kg). Hemodialysis was not performed.
Measurements And Main Results:
Iterative determination of ethylene glycol concentration was obtained in blood and urine. Kinetics were calculated for ethylene glycol and fomepizole elimination. The infant made a complete recovery with no change in renal function.
Conclusions:
Although not yet approved for this indication in the child, fomepizole seemed safe and effective in a case of severe ethylene glycol poisoning, without the need for hemodialysis.
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