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Synthesis of DNA mimics representing HypNA-pPNA hetero-oligomers
Vladimir A Efimov1, Oksana G Chakhmakhcheva
1Institute of Bio-organic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Abstract:
The methods for the synthesis and purification of negatively charged peptide nucleic acid (PNA)-relative deoxyribonucleic acid (DNA) mimics containing alternating residues of phosphono peptide nucleic acid (pPNA) monomers and PNA-like monomers on the base of trans-4-hydroxy-L-proline are described. Examples of the chimeric oligomers hybridization with complementary DNA and ribonucleic acid fragments are demonstrated.
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