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Related Experiment Videos

Supplemental screening sonography in dense breasts.

Wendie A Berg1

  • 1Study Chair ACRIN Protocol 6666, Lutherville, MD 21093, USA. wendieberg@hotmail.com

Radiologic Clinics of North America
|September 1, 2004
PubMed
Summary
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Screening breast ultrasound detected 150 cancers in average-risk women, with most invasive and node-negative. This supports further research into ultrasound

Area of Science:

  • Radiology
  • Oncology
  • Breast Imaging

Background:

  • Breast density is a significant risk factor for breast cancer.
  • Mammography may have limitations in detecting cancers in women with dense breasts.

Purpose of the Study:

  • To evaluate the effectiveness of screening sonography in detecting breast cancers.
  • To assess the characteristics of cancers detected solely by sonography.

Main Methods:

  • Analysis of single-center trial data from 42,838 examinations.
  • Identification of cancers detected exclusively through sonography.
  • Characterization of breast parenchyma density in women with sonographically detected cancers.

Main Results:

  • 150 cancers (0.35%) were identified solely by sonography in average-risk women.

Related Experiment Videos

  • Over 90% of these cancers occurred in women with dense or heterogeneously dense breasts.
  • 141 (94%) of the cancers were invasive, with a mean size of 9-11 mm and over 90% node-negative.

    • Conclusions:

    • Sonography can detect invasive, node-negative breast cancers, particularly in women with dense breasts.
    • Results support the potential role of supplemental screening sonography for women with dense breast parenchyma.
    • A multicenter trial (ACRIN Protocol 6666) is underway to further investigate screening sonography in high-risk women.