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CD23 expression in aged rats
V Chavez1, M Parreira Soares, H Bazin
1University of Louvain, Faculty of Medicine, Experimental Immunology Unit, Brussels, Belgium.
CD23 is considered as an activation marker. Its expression on lymphocytes was studied during aging by using 1- to 142-week-old rats. Before analysis, all animals were injected with monoclonal IgE, in order to detect their full expression of CD23 molecules on their lymphocyte surface membranes. In elderly rats, a decrease was observed in the percentages of CD23+ lymphocytes from mesenteric lymph nodes, spleen, Peyer's patches and peripheral blood. In addition, these lymphocytes expressed significantly fewer CD23 molecules per cell. Almost all CD23+ cells belonged to the B lineage and were bearing both IgM and IgD on their membranes. It is suggested that a decrease in the number of both IgM+IgD+CD23+ lymphocytes and CD23 molecules per cell may contribute to immune deficiency in the elderly.
CD23 is considered as an activation marker. Its expression on lymphocytes was studied during aging by using 1- to 142-week-old rats. Before analysis, all animals were injected with monoclonal IgE, in order to detect their full expression of CD23 molecules on their lymphocyte surface membranes. In elderly rats, a decrease was observed in the percentages of CD23+ lymphocytes from mesenteric lymph nodes, spleen, Peyer's patches and peripheral blood. In addition, these lymphocytes expressed significantly fewer CD23 molecules per cell. Almost all CD23+ cells belonged to the B lineage and were bearing both IgM and IgD on their membranes. It is suggested that a decrease in the number of both IgM+IgD+CD23+ lymphocytes and CD23 molecules per cell may contribute to immune deficiency in the elderly.