Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Linear poly(ethylene oxide)-based polyurethane hydrogels: polyurethane-ureas and polyurethane-amides.

P Petrini1, M C Tanzi, C R Moran

  • 1Department of Bioengineering, Politecnico di Milano, Piazza L. Da Vinci, 32, 20133 Milan, Italy.

Journal of Materials Science. Materials in Medicine
|September 7, 2004
PubMed
Summary

Linear polyurethane-amides (PUAs) based on poly(ethylene oxide) did not form hydrogels due to insufficient phase separation. However, crosslinked PUAs using maleic acid demonstrated promising hydrogel properties for biomedical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel on-a-chip system with a 3D-bioinspired gut mucus suitable to investigate bacterial endotoxins dynamics.

Materials today. Bio·2024
Same author

Engineering biological gradients.

Journal of applied biomaterials & functional materials·2019
Same author

Polyurethane foam/nano hydroxyapatite composite as a suitable scaffold for bone tissue regeneration.

Materials science & engineering. C, Materials for biological applications·2017
Same author

Factor IX inhibitors and anaphylaxis in hemophilia B.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Evaluating outcome of prophylaxis in haemophilia: objective and self-reported instruments should be combined.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Programmed cell delivery from biodegradable microcapsules for tissue repair.

Journal of biomaterials science. Polymer edition·2015

Area of Science:

  • Polymer Science
  • Biomaterials Engineering

Background:

  • Hydrogels are crucial in biomedical applications, with both water-swellable and water-insoluble types extensively studied.
  • Linear polyurethane-ureas (PUUs) exhibit hydrogel behavior due to phase-separated morphology, unlike typical crosslinked hydrogels.

Purpose of the Study:

  • To investigate the potential of creating linear poly(ethylene oxide)-based polyurethane-amide (PUA) hydrogels.
  • To evaluate PUA materials synthesized with amide diols and maleic acid as chain extenders.

Main Methods:

  • Employed a "one-shot" bulk polymerization technique for synthesizing poly(ethylene oxide)-based PUAs.
  • Conducted physicochemical characterization and water-solubility tests on the synthesized materials.

Main Results:

Related Experiment Videos

  • Linear PUAs, despite similar molecular weights to PUUs, failed to exhibit hydrogel behavior.
  • Insufficient phase separation, hydrogen bonding, and hard segment hydrophobicity were identified as limiting factors in linear PUAs.
  • Crosslinked PUAs utilizing maleic acid as a chain extender displayed notable hydrogel properties.

Conclusions:

  • Linear PUA synthesis using amide diols and maleic acid did not yield hydrogels.
  • Crosslinking linear PUAs with maleic acid is a viable strategy for developing hydrogel materials with potential biomedical uses.