Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydroxyapatite implants with designed internal architecture.

T M Chu1, J W Halloran, S J Hollister

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. ctmin@engin.umich.edu

Journal of Materials Science. Materials in Medicine
|September 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A fast-degrading thiol-acrylate based hydrogel for cranial regeneration.

Biomedical materials (Bristol, England)·2017
Same author

Purification of a Human Prostate Specific Antigen.

The Journal of urology·2016
Same author

Development of an oral mucosa equivalent using a porcine dermal matrix.

The British journal of oral & maxillofacial surgery·2016
Same author

Evaluation of multi-scale mineralized collagen-polycaprolactone composites for bone tissue engineering.

Journal of the mechanical behavior of biomedical materials·2016
Same author

3D-printed Bioresorbable Scaffold for Periodontal Repair.

Journal of dental research·2015
Same author

Biochemical indicators of implantation success of tissue-engineered oral mucosa.

Journal of dental research·2014
Same journal

Zinc-polydopamine nanozyme promotes mitochondrial biogenesis and alleviates inflammation and muscle atrophy during the perioperative period of surgery.

Journal of materials science. Materials in medicine·2026
Same journal

Immuno-instructive biomaterials for coronary artery disease and myocardial infarction repair.

Journal of materials science. Materials in medicine·2026
Same journal

Effect of topical nanoemulsion of minoxidil on animal hair growth: an in vivo study.

Journal of materials science. Materials in medicine·2026
Same journal

Selective cytotoxicity of zinc peroxide and tetrapodal zinc oxide micro-nanoparticles against breast cancer cells: synthesis, characterization, and therapeutic potential.

Journal of materials science. Materials in medicine·2026
Same journal

Progress and challenges of tantalum-containing biomaterials in regenerative medicine applications.

Journal of materials science. Materials in medicine·2026
Same journal

Synchronizing degradation with regeneration: a model-driven framework for designing biodegradable biomaterials in bone tissue engineering.

Journal of materials science. Materials in medicine·2026
See all related articles

A novel lost-mold technique using stereolithography enables precise control over porous hydroxyapatite (HA) bone graft structures. This method allows for designed pore channels, improving HA implant manufacturing for better bone regeneration.

Area of Science:

  • Biomaterials Science
  • Ceramic Engineering
  • Additive Manufacturing

Background:

  • Porous hydroxyapatite (HA) is a widely used bone graft material.
  • Traditional methods offer limited control over pore structure.
  • Advanced techniques are needed for tailored HA implants.

Purpose of the Study:

  • To develop a new method for manufacturing porous HA with designed pore channels.
  • To achieve precise control over pore size, shape, and interconnectivity in HA implants.
  • To explore the potential of stereolithography-based lost-mold technique for HA fabrication.

Main Methods:

  • Utilized Computer-Aided Design (CAD) and Computer Tomography (CT) data to design pore channels.
  • Fabricated negative molds using stereolithography with epoxy resins.

Related Experiment Videos

  • Formulated a highly loaded HA suspension and cast it into the molds.
  • Cured, pyrolyzed, and sintered the HA green bodies to create porous implants.

    • Main Results:

    • Successfully manufactured HA implants with six different designed channel patterns.
    • Reproducibly created channels ranging from 366 to 968 micrometers in diameter.
    • Achieved controlled porosity between 26% and 52% through designed channels.
    • Demonstrated the capability to produce HA implants with designed connection patterns and controlled channel sizes.

    Conclusions:

    • The developed lost-mold technique offers precise control over pore structure in HA implants.
    • This method enables the fabrication of customized HA bone grafts with designed architecture.
    • The technique holds significant promise for advancing bone graft material design and clinical application.