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Published on: September 21, 2017
Chimeric (aeg-pyrrolidine)PNAs: synthesis and stereo-discriminative duplex binding with DNA/RNA
Pallavi S Lonkar1, Krishna N Ganesh, Vaijayanti A Kumar
1Division of Organic Chemistry, Synthesis, National Chemical Laboratory, Pune 411008, India. vakumar@dalton.ncl.res.in
Abstract:
The design and facile conversion of naturally occurring 4-hydroxyproline to all four diastereomers of thymine pyrrolidine PNA monomer, (2R,4S)-adenine, -guanine and -cytosine monomers and their incorporation into duplex forming PNA oligomers is reported. The interesting results of the hybridization studies with complementary DNA/RNA sequences in either parallel or antiparallel orientation reveal the stereochemistry-dependent DNA vs. RNA discriminations and parallel/antiparallel orientation selectivity.
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