Stevens-Johnson syndrome after immunization with smallpox, anthrax, and tetanus vaccines

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Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination
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Optimized Interferon-gamma ELISpot Assay to Measure T Cell Responses in the Guinea Pig Model after Vaccination

Published on: January 20, 2019

Ashish Chopra1, Lisa A Drage, Eric M Hanson

  • 1Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA.

Mayo Clinic Proceedings
|September 11, 2004
PubMed

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
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