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Trends in Patch Testing With the Mayo Clinic Standard Series, 2017-2021.

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Patch testing identifies contact dermatitis allergens. Hydroperoxides of linalool and limonene are newly identified common allergens, showing high reaction rates in recent patient data.

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Area of Science:

  • Dermatology
  • Allergology
  • Epidemiology

Background:

  • Patch testing is crucial for diagnosing contact dermatitis by identifying causative allergens.
  • Allergen reaction rates change over time due to evolving population exposures.
  • Previous studies established baseline reaction rates for standard allergen series.

Purpose of the Study:

  • To analyze patch test results from the Mayo Clinic standard series between 2017 and 2021.
  • To compare current findings with historical data (2011-2015) and the North American Contact Dermatitis Group (NACDG) report (2017-2018).
  • To identify prevalent allergens and trends in contact dermatitis.

Main Methods:

  • Retrospective review of patch test reactions to the standard series from 2017-2021.
  • Comparison of reaction rates with prior Mayo Clinic data and the NACDG report.
  • Analysis of 2667 patient test results.

Main Results:

  • Over 63% of patients (1683/2667) exhibited at least one positive patch test reaction.
  • The top 15 allergens included hydroperoxides of linalool (1% and 0.5%), methylisothiazolinone, Myroxylon pereirae resin, and fragrance mix I.
  • Twelve of the top 15 allergens identified were consistent with the NACDG report.
  • Newly added allergens, hydroperoxides of linalool and limonene, demonstrated high reaction rates.

Conclusions:

  • Hydroperoxides of linalool and limonene are significant allergens associated with high reaction rates in the studied population.
  • Current patch test results show considerable overlap with national data, indicating consistent allergen prevalence.
  • Ongoing monitoring of patch test results is essential for understanding and managing contact dermatitis trends.